Bioinformatics Manager I/II
December 17, 2021
Bioinformatics Manager I/II
Job ID: req2294
Employee Type: exempt full-time
Division: Biomedical Informatics & Data Science
Facility: NIH
Location: NIH Campus 9000 Rockville Pike, Bethesda, MD 20892 USA
The Frederick National Laboratory is a Federally Funded Research and Development Center (FFRDC) sponsored by the National Cancer Institute (NCI) and operated by Leidos Biomedical Research, Inc. The lab addresses some of the most urgent and intractable problems in the biomedical sciences in cancer and AIDS, drug development and first-in-human clinical trials, applications of nanotechnology in medicine, and rapid response to emerging threats of infectious diseases.
Accountability, Compassion, Collaboration, Dedication, Integrity and Versatility; it's the FNL way.
Position Overview:
PROGRAM DESCRIPTION
The Frederick National Laboratory is dedicated to improving human health through the discovery and innovation in the biomedical sciences, focusing on cancer, AIDS and emerging infectious diseases.
The Biomedical Informatics and Data Science (BIDS) directorate works collaboratively and helps to fulfill the mission of Frederick National Laboratory in the areas of biomedical informatics and data science by developing and applying world leading data science and computing technologies to basic and applied biomedical research challenges, supporting critical operations, developing and delivering national data resources, and employing leading-edge software and data science.
The Advanced Biomedical and Computational Science (ABCS) group is a part of BIDS within Leidos Biomedical Research as a technological hub of translational scientists with expertise in structural biology, biology, chemistry, imaging, and informatics. ABCS develops state-of-the-art technologies in large-scale data modeling, analysis, and integration and supports the scientific research at the Frederick National Lab by helping translate scientific questions to technical solutions for cancer and biomedical research.
The Genetics Branch (GB, Center for Cancer Research, NCI, https://ccr.cancer.gov/Genetics-Branch ) undertakes basic research as well as clinical and translational research activities. Under the purview of the basic research umbrella, the branch conducts research on the elucidation of the necessary and sufficient factors that govern genetic instability, the description of common/disparate themes among different types of instability, and the cataloging of distinct patterns of gene expression in tumors compared to normal tissues. Under the mantle of clinical research, the branch undertakes patient cancer risk screening, education, counseling, genetic testing, and the development of appropriate surveillance and prevention options that take into account the category of risk that an individual patient, family, or population represents. The translational research that supports this clinical enterprise consists of four components: (1) molecular diagnostics; (2) genotype/phenotype correlations; (3) the development of biomarkers that can be used for risk assessment and as intermediate endpoints for chemoprevention trials; and (4) targeted therapy and assays for active agents based on the underlying genetics and mechanism(s) of genetic instability that distinguish a tumor from the normal cells from which it arose. Under the leadership of Dr. Paul Meltzer (Chief) and Dr. Javed Khan (Deputy Chief), the branch comprises of several research groups led by Principal Investigators focusing on complementary areas of interest. In FY 2021, the Genetics Branch (GB) formed an OMICS facility which will provide access to state-of-the-art OMICS technologies and computational biology resources and support to GB Investigators. The OMICS facility also plans on developing and implementing tools for data integration and databases to allow easy access to all the data for all staff in the branch including trainees.
KEY ROLES/RESPONSIBILITIES
BASIC QUALIFICATIONS
To be considered for this position, you must minimally meet the knowledge, skills, and abilities listed below:
PREFERRED QUALIFICATIONS
Candidates with these desired skills will be given preferential consideration:
Equal Opportunity Employer (EOE) | Minority/Female/Disabled/Veteran (M/F/D/V) | Drug Free Workplace (DFW)
As directed by Executive Order 14042: Ensuring Adequate COVID Safety Protocols for Federal Contractors, effective December 8, 2021, Frederick National Laboratory (FNL) will require employees of Leidos Biomedical Research (LBR) and all newly hired employees before their start date, in the United States, to be fully vaccinated or have a qualified exemption.
#readytowork
Job ID: req2294
Employee Type: exempt full-time
Division: Biomedical Informatics & Data Science
Facility: NIH
Location: NIH Campus 9000 Rockville Pike, Bethesda, MD 20892 USA
The Frederick National Laboratory is a Federally Funded Research and Development Center (FFRDC) sponsored by the National Cancer Institute (NCI) and operated by Leidos Biomedical Research, Inc. The lab addresses some of the most urgent and intractable problems in the biomedical sciences in cancer and AIDS, drug development and first-in-human clinical trials, applications of nanotechnology in medicine, and rapid response to emerging threats of infectious diseases.
Accountability, Compassion, Collaboration, Dedication, Integrity and Versatility; it's the FNL way.
Position Overview:
PROGRAM DESCRIPTION
The Frederick National Laboratory is dedicated to improving human health through the discovery and innovation in the biomedical sciences, focusing on cancer, AIDS and emerging infectious diseases.
The Biomedical Informatics and Data Science (BIDS) directorate works collaboratively and helps to fulfill the mission of Frederick National Laboratory in the areas of biomedical informatics and data science by developing and applying world leading data science and computing technologies to basic and applied biomedical research challenges, supporting critical operations, developing and delivering national data resources, and employing leading-edge software and data science.
The Advanced Biomedical and Computational Science (ABCS) group is a part of BIDS within Leidos Biomedical Research as a technological hub of translational scientists with expertise in structural biology, biology, chemistry, imaging, and informatics. ABCS develops state-of-the-art technologies in large-scale data modeling, analysis, and integration and supports the scientific research at the Frederick National Lab by helping translate scientific questions to technical solutions for cancer and biomedical research.
The Genetics Branch (GB, Center for Cancer Research, NCI, https://ccr.cancer.gov/Genetics-Branch ) undertakes basic research as well as clinical and translational research activities. Under the purview of the basic research umbrella, the branch conducts research on the elucidation of the necessary and sufficient factors that govern genetic instability, the description of common/disparate themes among different types of instability, and the cataloging of distinct patterns of gene expression in tumors compared to normal tissues. Under the mantle of clinical research, the branch undertakes patient cancer risk screening, education, counseling, genetic testing, and the development of appropriate surveillance and prevention options that take into account the category of risk that an individual patient, family, or population represents. The translational research that supports this clinical enterprise consists of four components: (1) molecular diagnostics; (2) genotype/phenotype correlations; (3) the development of biomarkers that can be used for risk assessment and as intermediate endpoints for chemoprevention trials; and (4) targeted therapy and assays for active agents based on the underlying genetics and mechanism(s) of genetic instability that distinguish a tumor from the normal cells from which it arose. Under the leadership of Dr. Paul Meltzer (Chief) and Dr. Javed Khan (Deputy Chief), the branch comprises of several research groups led by Principal Investigators focusing on complementary areas of interest. In FY 2021, the Genetics Branch (GB) formed an OMICS facility which will provide access to state-of-the-art OMICS technologies and computational biology resources and support to GB Investigators. The OMICS facility also plans on developing and implementing tools for data integration and databases to allow easy access to all the data for all staff in the branch including trainees.
KEY ROLES/RESPONSIBILITIES
- Work independently and with management to identify and define technical requirements for tasks and timelines
- Report project status regularly to management and stakeholders
- Maintain code repository (eg. GitHub), container repository (eg. DockerHub) and pipeline repository (eg. Dockstore )
- Respond to new feature requests, assist issues raised by userbase and co-ordinate change management
- Plan code and resource-bundle release cycles prioritizing high-demand customer feature requests
- Provide technical direction and guidance to the team on pipeline design, data management and data analysis efforts
- Participate in lab/branch meetings, bioinformatics group meetings as well as meetings with GB collaborators
- Participate in hiring related activities (screening candidates, interviewing, onboarding and mentoring)
- Provide project management support (ensure that all projects are logged, tracked and updated routinely)
- Provide timely reporting as and when required by GB as well as ABCS management
- Be abreast of literature on cancer genomics as well as NGS tools/technologies
- Provide consultations on experimental and sequencing design as well as data management
- Ensure that pipelines/approaches developed by the analysts follow best practices in consultation with senior analysts in CCBR
- Will have a responsibility to work with the BIDS PAO as may be required
- Other duties as required
BASIC QUALIFICATIONS
To be considered for this position, you must minimally meet the knowledge, skills, and abilities listed below:
- Possession of a Bachelor's degree from an accredited college/university according to the Council for Higher Education Accreditation (CHEA) in computer science, Bioinformatics, Biomedical Scienceor a related field or four (4) years relevant experience in lieu of degree. Foreign degrees must be evaluated for U.S. equivalency
- Bioinformatics Manager l - minimum four (4) years of progressively responsible experience, including two (2) years of experience in a supervisory/leadership capacity
- Bioinformatics Manager lI - minimum six (6) years of progressively responsible experience, including four (4) years of experience in a supervisory/leadership capacity
- Experience managing bioinformatics and/or data science analysts
- Expertise in R and Python
- Experience with Unix/Linux OS scripting
- Experience with high performance computing
- Excellent knowledge of scientific data sets in the public domain
- Excellent written and verbal communication skills/ability to document and communicate complexscientificconcepts for a variety of audiences
- Competency in working with Unix command line and scripting languages
- Ability to obtain and maintain a security clearance
PREFERRED QUALIFICATIONS
Candidates with these desired skills will be given preferential consideration:
- Possession of a Masters' or Ph.D. degree in any quantitative science is preferred
- Commitment to solving biological problems and communicating these solutions
- Ability to multi-task across projects
- Experience in submitting data sets to public repositories
- Management of large genomic data sets including integration with data available from public sources
- Prior customer-facing role
- Record of scientific achievements including journal publications and conference presentations
- Experience evaluating and comparing different computational pipelines for alignment, variant calling, and functional annotation
Equal Opportunity Employer (EOE) | Minority/Female/Disabled/Veteran (M/F/D/V) | Drug Free Workplace (DFW)
As directed by Executive Order 14042: Ensuring Adequate COVID Safety Protocols for Federal Contractors, effective December 8, 2021, Frederick National Laboratory (FNL) will require employees of Leidos Biomedical Research (LBR) and all newly hired employees before their start date, in the United States, to be fully vaccinated or have a qualified exemption.
#readytowork