Assay Development Scientist - Biochemistry
November 12, 2022
Assay Development Scientist - Biochemistry
Job ID: req2509
Employee Type: exempt full-time
Division: Cancer Research Technology Program
Facility: Frederick: ATRF
Location: 8560 Progress Dr, Frederick, MD 21701 USA
The Frederick National Laboratory is a Federally Funded Research and Development Center (FFRDC) sponsored by the National Cancer Institute (NCI) and operated by Leidos Biomedical Research, Inc. The lab addresses some of the most urgent and intractable problems in the biomedical sciences in cancer and AIDS, drug development and first-in-human clinical trials, applications of nanotechnology in medicine, and rapid response to emerging threats of infectious diseases.
Accountability, Compassion, Collaboration, Dedication, Integrity and Versatility; it's the FNL way.
***THIS POSITION CAN BE FILLED AT EITHER THE SCIENTIST I OR SCIENTIST II LEVEL***
PROGRAM DESCRIPTION
The primary goal of the NCI RAS Initiative is to discover new therapeutic interventions against RAS-driven cancers. The NCI RAS Initiative is composed of multiple groups focused on protein science, biochemistry/biophysics, structural biology, molecular imaging, computational and medicinal chemistry, and drug discovery. By understanding the basic biology of RAS, we aim to identify novel vulnerabilities that allow direct targeting of the mutant protein. The RAS Biochemistry/Biophysics group is responsible for developing novel assays to interrogate RAS activity and use these to identify small molecule inhibitors.
KEY ROLES/RESPONSIBILITIES
BASIC QUALIFICATIONS
To be considered for this position, you must minimally meet the knowledge, skills, and abilities listed below:
PREFERRED QUALIFICATIONS
Candidates with these desired skills will be given preferential consideration:
Equal Opportunity Employer (EOE) | Minority/Female/Disabled/Veteran (M/F/D/V) | Drug Free Workplace (DFW)
#readytowork
Job ID: req2509
Employee Type: exempt full-time
Division: Cancer Research Technology Program
Facility: Frederick: ATRF
Location: 8560 Progress Dr, Frederick, MD 21701 USA
The Frederick National Laboratory is a Federally Funded Research and Development Center (FFRDC) sponsored by the National Cancer Institute (NCI) and operated by Leidos Biomedical Research, Inc. The lab addresses some of the most urgent and intractable problems in the biomedical sciences in cancer and AIDS, drug development and first-in-human clinical trials, applications of nanotechnology in medicine, and rapid response to emerging threats of infectious diseases.
Accountability, Compassion, Collaboration, Dedication, Integrity and Versatility; it's the FNL way.
***THIS POSITION CAN BE FILLED AT EITHER THE SCIENTIST I OR SCIENTIST II LEVEL***
PROGRAM DESCRIPTION
The primary goal of the NCI RAS Initiative is to discover new therapeutic interventions against RAS-driven cancers. The NCI RAS Initiative is composed of multiple groups focused on protein science, biochemistry/biophysics, structural biology, molecular imaging, computational and medicinal chemistry, and drug discovery. By understanding the basic biology of RAS, we aim to identify novel vulnerabilities that allow direct targeting of the mutant protein. The RAS Biochemistry/Biophysics group is responsible for developing novel assays to interrogate RAS activity and use these to identify small molecule inhibitors.
KEY ROLES/RESPONSIBILITIES
- Develop plate-based biochemical assays for drug discovery programs
- Supervise technical staff responsible for biochemical drug screening
- Analyze data, prepare reports/presentations to share with the team
- Develop biochemical or biophysical assays to interrogate RAS biology
- Interact with structural biology and drug discovery groups to align assay development
BASIC QUALIFICATIONS
To be considered for this position, you must minimally meet the knowledge, skills, and abilities listed below:
- Possession of PhD degree in science from an accredited college/university according to the Council for Higher Education Accreditation (CHEA) or eight (8) years relevant experience in lieu of degree. Foreign degrees must be evaluated for U.S. equivalency
- Level I - No experience beyond education requirement
- Level II - In addition to education requirement, a minimum of two (2) years of related experience
- Expertise with biochemical plate-based assays
- Experience in protein/protein interaction assays using time resolved fluorescence methods
- Knowledge of fluorescence or luminescence methods to assay for protein activity
- Experience in analyzing small molecule inhibitors
- Ability to obtain and maintain a security clearance
PREFERRED QUALIFICATIONS
Candidates with these desired skills will be given preferential consideration:
- Experience using Homogeneous Time-Resolved Fluorescence (HTRF) for protein/protein interaction assays
- Previous experience in drug discovery programs
- Knowledge of biochemical and biophysical assays for protein/protein interaction
- Knowledge of protein enzymology
Equal Opportunity Employer (EOE) | Minority/Female/Disabled/Veteran (M/F/D/V) | Drug Free Workplace (DFW)
#readytowork