Bioinformatics Analyst III, Biostatistics Branch, CGR - Remote

Job ID: req2665
Employee Type: exempt full-time
Division: Clinical Research Program
Facility: Rockville: 9609 MedCtrDr
Location: 9609 Medical Center Dr, Rockville, MD 20850 USA

The Frederick National Laboratory is a Federally Funded Research and Development Center (FFRDC) sponsored by the National Cancer Institute (NCI) and operated by Leidos Biomedical Research, Inc. The lab addresses some of the most urgent and intractable problems in the biomedical sciences in cancer and AIDS, drug development and first-in-human clinical trials, applications of nanotechnology in medicine, and rapid response to emerging threats of infectious diseases.

Accountability, Compassion, Collaboration, Dedication, Integrity and Versatility; it's the FNL way.

PROGRAM DESCRIPTION
The Cancer Genomics Research (CGR) laboratory in Gaithersburg, MD, is a fast-paced, high-throughput organization dedicated to the support of molecular, genetic and epidemiologic studies for investigators at the National Cancer Institute's Division of Cancer Epidemiology & Genetics (DCEG). The Division includes over 70 principal investigators in epidemiology, genetics, and biostatistics who conduct multidisciplinary family- and population-based research to discover the genetic and environmental determinants of cancer, and new approaches to cancer prevention. This includes the design and analysis of high throughput studies using various types of "-omics" technologies such as array- and sequence-based genome-wide association studies, studies of tumor characteristics using integrated genomic data analysis and molecular epidemiologic studies based on novel metabolomic and macrobiotic assays. Within DCEG, the Biostatistics Branch (BB) staff and Investigators develop statistical methods and data resources to strengthen observational studies, intervention trials, and laboratory investigations of cancer. DCEG/BB is requesting the addition of computational support, to be provided through CGR, to support methods for genomic studies including GWAS analysis, somatic mutation analysis, and integrative tumor analysis. We are seeking a highly motivated bioinformatics analyst to join the bioinformatics team at the CGR and provide dedicated analytical support to BB within DCEG. Working with DCEG investigators, external collaborators, CGR management and staff, the successful incumbent will provide leadership and support to the extensive DCEG analytical efforts, specifically:

KEY ROLES/RESPONSIBILITIES

• Provide support to BB studies and stay current with CGR and other division-wide bioinformatics activities/processes
• Review, QC, and integrate data from multiple sources (multi-omics studies), primarily focused on germline genotyping and sequencing data, with some additional somatic sequencing, transcription, and methylation data
• Contributing to the solutions of multi-omics analysis pipelines through exploring novel software, benchmarking, comparisons, testing, and troubleshooting
• Organizing results into clear presentations and concise summaries of work, in formats useful for scientific interpretation
• Facile use of computational resources both within DCEG, CGR and in the cloud
• Document all analyses and pipelines used in support of reproducible research
• Develop and execute advanced analyses including multiplicative interaction analyses, pathway-based analyses, integrative analyses
• Work closely with DCEG PIs in support of scientific manuscript development, submission, revision activities with significant co-authorship opportunities

BASIC QUALIFICATIONS

To be considered for this position, you must minimally meet the knowledge, skills, and abilities listed below:

• Possession of a bachelor's degree from an accredited college or university according to the Council for Higher Education Accreditation (CHEA) in bioinformatics, computer science, computational biology or related field. Foreign degrees must be evaluated for U.S. equivalency
• In addition to educational requirements, a minimum of five (5) years of related analytical or bioinformatics pipeline development experience
• Hands-on experience in processing sequencing, genotyping, expression, and other data utilizing bioinformatics tools
• The ability to construct practical computational tools for data parsing, quality control, modelling and analysis for large-scale genetic or genomics datasets
• Demonstrable shell scripting skills (e.g., bash, awk, sed)
• Experience working in a Linux environment (especially a high-performance computing cluster environment)
• Strong programming skills (e.g., in one or more of R, Python, C/C++, Perl, Java)
• Ability to obtain and maintain a security clearance

PREFERRED QUALIFICATIONS

Candidates with these desired skills will be given preferential consideration:

• Masters strongly preferred
• Familiarity with public genomic tools, databases, and utilities
• Experience managing large datasets and computational tasks
• Experience in the field of molecular and population genetics with a strong publication record
• Expertise in statistical programming and data manipulation (e.g. R, MATLAB) is desired
• Team oriented with demonstrated ability to mentor others as well as self-educate in current bioinformatics techniques and resources
• Excellent written and oral communication-ability to communicate clearly and effectively with staff and other groups within CGR and DCEG, and able to interpret data and write scientific reports as well as other written communications

Equal Opportunity Employer (EOE) | Minority/Female/Disabled/Veteran (M/F/D/V) | Drug Free Workplace (DFW)

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