Research Associate II
October 9, 2022
Research Associate II
Job ID: req2744
Employee Type: exempt full-time
Division: Applied & Development Research Program
Facility: Frederick: Ft Detrick
Location: PO Box B, Frederick, MD 21702 USA
The Frederick National Laboratory is a Federally Funded Research and Development Center (FFRDC) sponsored by the National Cancer Institute (NCI) and operated by Leidos Biomedical Research, Inc. The lab addresses some of the most urgent and intractable problems in the biomedical sciences in cancer and AIDS, drug development and first-in-human clinical trials, applications of nanotechnology in medicine, and rapid response to emerging threats of infectious diseases.
Accountability, Compassion, Collaboration, Dedication, Integrity and Versatility; it's the FNL way.
PROGRAM DESCRIPTION
The Frederick National Laboratory for Cancer Research (FNL) is a Federally Funded Research and Development Center sponsored by the National Cancer Institute (NCI) and operated by the prime contractor Leidos Biomedical Research, Inc. FNL is responsible for pursuing a unique mission in translational and applied biomedical research that is unsuitable for academia, the pharmaceutical industry, or other federal contractors. This open position in is ideally suited for a person who is more interested in applied Research & Development than in pursuing basic research knowledge. The selected candidate will join the Clinical Pharmacodynamic (PD) Biomarkers support group located at the NCI-Frederick campus.
The Clinical PD Biomarkers Program is responsible for identification of biomarkers of response to new targeted agents entering clinical trials in the Developmental Therapeutics Program of the NCI. The scope of work includes assay design, development, validation, fitness for purpose testing, transfer of assays to clinical laboratories, and clinical specimen analysis when required. The program facilitates mechanistic and performance analysis of putative anti-cancer agents, diagnostic tests, and therapeutic interventions to clinical applications, including distinct molecular signatures for cancer, refined molecular assays, and state-of-the-art imaging techniques. The program operates a number of advanced, specialized instrumentation for image analysis of tumor biopsies, circulating tumor cells, and activated Tcells for measuring drug effects in patients enrolled in clinical trials.
KEY ROLES/RESPONSIBILITIES
BASIC QUALIFICATIONS
To be considered for this position, you must minimally meet the knowledge, skills, and abilities listed below:
PREFERRED QUALIFICATIONS
Candidates with these desired skills will be given preferential consideration:
JOB HAZARDS
Equal Opportunity Employer (EOE) | Minority/Female/Disabled/Veteran (M/F/D/V) | Drug Free Workplace (DFW)
#readytowork
Job ID: req2744
Employee Type: exempt full-time
Division: Applied & Development Research Program
Facility: Frederick: Ft Detrick
Location: PO Box B, Frederick, MD 21702 USA
The Frederick National Laboratory is a Federally Funded Research and Development Center (FFRDC) sponsored by the National Cancer Institute (NCI) and operated by Leidos Biomedical Research, Inc. The lab addresses some of the most urgent and intractable problems in the biomedical sciences in cancer and AIDS, drug development and first-in-human clinical trials, applications of nanotechnology in medicine, and rapid response to emerging threats of infectious diseases.
Accountability, Compassion, Collaboration, Dedication, Integrity and Versatility; it's the FNL way.
PROGRAM DESCRIPTION
The Frederick National Laboratory for Cancer Research (FNL) is a Federally Funded Research and Development Center sponsored by the National Cancer Institute (NCI) and operated by the prime contractor Leidos Biomedical Research, Inc. FNL is responsible for pursuing a unique mission in translational and applied biomedical research that is unsuitable for academia, the pharmaceutical industry, or other federal contractors. This open position in is ideally suited for a person who is more interested in applied Research & Development than in pursuing basic research knowledge. The selected candidate will join the Clinical Pharmacodynamic (PD) Biomarkers support group located at the NCI-Frederick campus.
The Clinical PD Biomarkers Program is responsible for identification of biomarkers of response to new targeted agents entering clinical trials in the Developmental Therapeutics Program of the NCI. The scope of work includes assay design, development, validation, fitness for purpose testing, transfer of assays to clinical laboratories, and clinical specimen analysis when required. The program facilitates mechanistic and performance analysis of putative anti-cancer agents, diagnostic tests, and therapeutic interventions to clinical applications, including distinct molecular signatures for cancer, refined molecular assays, and state-of-the-art imaging techniques. The program operates a number of advanced, specialized instrumentation for image analysis of tumor biopsies, circulating tumor cells, and activated Tcells for measuring drug effects in patients enrolled in clinical trials.
KEY ROLES/RESPONSIBILITIES
- Pharmacodynamic multiplex immunoassay development, validation, and analysis of cancer agent activity in preclinical and/or clinical specimens
- Screening of reagents suitable for multiplex assay development
- Developing and optimizing multiplex assays
- Developing appropriate quality control processes
- Converting assay working procedures into detailed standard operating procedures (SOPs)
- Processing of animal tissues and cancer cell lines into lysates for analysis
- Performing general lab duties to maintain laboratory equipment and to ensure compliance with regulations
- Performing in-vitro pharmacodynamic monitoring experiments using cancer cell lines
- Interacting with supervisor throughout the experimental process from study design to result interpretation
BASIC QUALIFICATIONS
To be considered for this position, you must minimally meet the knowledge, skills, and abilities listed below:
- Possession of a (CHEA) Bachelor's degree from an accredited college or university according to the Council for Higher Education Accreditation. (Additional qualifying experience may be substituted for the required education) Foreign degrees will be evaluated for U.S. equivalency
- In addition to the educational requirements, a minimum of five (5) years of experience is required
- One year of laboratory experience in immunoassay development on Luminex or other multiplex assay platforms
- Experience in techniques used in immunoassay development such as SDS-PAGE, Western blotting, antibody characterization, conjugation of proteins, protein purification, and cell culture
- Experience in processing tumor samples for analysis by pharmacodynamic assays
- Ability to design and conduct experiments, process quality control data, and process results into presentable scientific reports
- Ability to perform basic laboratory math including some knowledge of basic statistical methodologies
- Ability to obtain and maintain a security clearance
PREFERRED QUALIFICATIONS
Candidates with these desired skills will be given preferential consideration:
- Completed laboratory science courses in one or more of the following: chemistry, biochemistry, pharmacology, or statistics
- Good computer skills
JOB HAZARDS
- This position is subject to working with or have potential for exposure to infectious material, requiring
medical clearance and immunizations - This position is subject to working in or have the potential to exposure to high noise levels for
extended periods of time requiring medical clearance
Equal Opportunity Employer (EOE) | Minority/Female/Disabled/Veteran (M/F/D/V) | Drug Free Workplace (DFW)
#readytowork