Bioinformatics Analyst

Job ID: req2895
Employee Type: exempt full-time
Division: Clinical Research Program
Facility: Frederick: Ft Detrick
Location: PO Box B, Frederick, MD 21702 USA

The Frederick National Laboratory is a Federally Funded Research and Development Center (FFRDC) sponsored by the National Cancer Institute (NCI) and operated by Leidos Biomedical Research, Inc. The lab addresses some of the most urgent and intractable problems in the biomedical sciences in cancer and AIDS, drug development and first-in-human clinical trials, applications of nanotechnology in medicine, and rapid response to emerging threats of infectious diseases.

Accountability, Compassion, Collaboration, Dedication, Integrity and Versatility; it's the FNL way.

PROGRAM DESCRIPTION

The Molecular Characterization Laboratory (MoCha) is part of Leidos Biomedical Research's Clinical Research Directorate (CRD) at the Frederick National Laboratory for Cancer Research. The MoCha Laboratory is responsible for providing high-level research in support of the NCI-Cancer Diagnostics Program (CDP) within the Division of Cancer Treatment and Diagnosis (DCTD). MoCha is charged with the development and application of genomic assays for use in medical research and diagnostics for DCTD-sponsored national extramural clinical trials.

KEY ROLES/RESPONSIBILITIES

• Provide substantial bioinformatics support for the MoCha laboratory, including the analysis and interpretation of high throughput genomic data
• Validate and maintain genomic analysis pipelines for exome, whole genome and RNA-seq data, single-cell RNA sequencing data, digital spatial transcriptomics data generated from the MoCha lab and/or collaborator(s)
• Provide expertise in the biological interpretation of results, including mutation impact assessment, expression analysis, statistics support and prioritization of identified loci/genes lists, classification model building and determining correlation with clinical data derived from patients
• Maintain and track complex data for multiple projects
• Work with lab managers to update genetic information in databases
• Provide support to lab staff in the application of basic data analysis and study design
• Work closely with clinical lab staff to provide computation resources and to support data analysis and storage
• Coordinate and integrate software applications and databases within the larger group including the Bethesda, Frederick, and Shady Grove NCI campuses
• This position is located in Frederick, MD

BASIC QUALIFICATIONS

To be considered for this position, you must minimally meet the knowledge, skills, and abilities listed below:

Analyst III, Bioinformatics

• Possession of Bachelor's degree from an accredited college/university according to the Council for Higher Education Accreditation (CHEA) Foreign degrees must be evaluated for U.S. equivalency
• In addition to the education requirement, a minimum of five (5) years of progressively responsible experience
  

Analyst IV, Bioinformatics

• Possession of Master's degree from an accredited college/university according to the Council for Higher Education Accreditation (CHEA) Foreign degrees must be evaluated for U.S. equivalency
• In addition to the education requirement, a minimum of ten (10) years of progressively responsible experience

Both the Bioinformatics Analyst III and IV positions require:

• Experience in next generation sequence analysis (NGS) including quality metrics, mapping, variant calling and biological interpretation, and experience with analysis of large genomic data sets including integration with data available from public or private sources
• Hands-on experience in data processing and analyzing DNA/RNA sequencing, expression, single-cell RNA sequencing, digital spatial transcriptomics and other array data including quality and biological assessment are also essential
• Proficiency in Unix (Linux) system, scripting and programming languages such as Shell, R, Python, JavaScript, Perl, Java, SQL and bioinformatics tools and database management
• Statistical analysis of complex biological data
• Experience and demonstrated success in a team-oriented environment and excellent communication skills (written and oral)
• Strong organizational skills and information tracking experience for data with complex structure
• Ability to identify and solve complex problems
• Ability to obtain and maintain a security clearance
  

Equal Opportunity Employer (EOE) | Minority/Female/Disabled/Veteran (M/F/D/V) | Drug Free Workplace (DFW)

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